Everyone wants various things in life and to get them we must usually take them from others. Morality should be based on a calculation of benefits and harms so that we can get what we desire without antagonizing others in the process.
There will never be a state of perfection in this world. We can, however, seek out challenges and hardships and apply our reason and ingenuity to overcome them. We can't be perfect but we can be just a little bit better every day.
This is probably the most important commandment we can include since it addresses the core problem with religious commandments: it allows us to discuss these commandments and REJECT them if need be. Rejecting the idea of absoluteness is something we need to include.
Knowledge is the result of collective actions; the exploitation of the commons allows humans to live, and thus to gain knowledge. When that knowledge is used via economic systems to claim ownership over the commons, one erases this deep link between life, commons and knowledge.
The idea that man has the right to dominate nature allows for a legitimization of the ruthless and unsustainable destruction of our living world. By believing the contrary, a more complex and ethical relation with nature forces itself into our actions.
Right from childhood, we're taught how to think, how to live and what to do. Society shapes us in every way, rewarding conformity and punishing otherwise. This leads to intellectual stagnation and unless we're free to question and understand everything in the world, we're doomed.
Current knowledge is in constant change. To adapt to new knowledge and not be rigid in our believes, while remaining curious, should be how we try and make sense of our surroundings.
We can only know what is true if we can show that it is true. And in cases where objectivity cannot be attained, opinions should always be open to discussion, criticism, and revision.